Substituted indoles

US7572796B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Oliver Schadt · Rodenbach, DE
• Henning Bottcher · Darmstadt, DE
• Joachim Leibrock · Gauting, DE
• Kai Schiemann · Darmstadt, DE
• Timo Heinrich · Groß-Umstadt, DE
• Gunter Holzemann · Seeheim-Jugenheim, DE
• Christoph van Amsterdam · Darmstadt, DE
• Gerd Bartoszyk · Weiterstadt, DE
• Christoph Seyfried · Seeheim-Jugenheim, DE

Key dates

• Filing date: Apr 11, 2003
• Grant date: Aug 11, 2009
• Expiry date: Sep 5, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted indoles of the formula (I) and physiologically acceptable derivatives and salts thereof, in which R1, D, E, R12, p, X1, E, G, X2 and Z are as defined in claim 1, exhibit particular actions on the central nervous system, especially 5HT reuptake-inhibiting and 5 HTx-agonistic and/or -antagonistic actions and in particular serotonin-agonistic and -antagonistic properties and can be employed as antipsychotics, neuroleptics, antidepressants, anxiolytics and/or antihypertonics. They can furthermore be employed as excitatory amino acid antagonists for combating neurodegenerative diseases, including cerebrovascular diseases, epilepsy, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's disease, cerebral ischaemia, infarction or psychoses.