Biaryl substituted triazoles as sodium channel blockers

US7572822B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Prasun K. Chakravarty · Edison, US
• William H. Parsons · Montgomery, US
• Brenda Palucki · Fryeburg, US
• Bishan Zhou · Edison, US
• Min K. Park · Whippany, US
• Michael H. Fisher · Bound Brook, US

Key dates

• Filing date: Jan 30, 2008
• Grant date: Aug 11, 2009
• Expiry date: Jan 30, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.