Biomimetic materials comprising polyhedral oligomeric silsesquioxanes

US7572872B2 · kind B2 · utility

Inventors

• Jason T. Flodin · Allentown, US
• Joseph D. Lichtenhan · Petal, US
• Joseph J. Schwab · Tecate Mission Road, US
• Yi-Zhong An · Irvine, US
• Xuan Fu · Purvis, US
• Zachary Kemp · Mendenhall, US

Key dates

• Filing date: Apr 24, 2006
• Grant date: Aug 11, 2009
• Expiry date: Jan 23, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2400/12
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Nanostructured chemicals such as polyhedral oligomeric silsesquioxanes, polyhedral oligomeric silicates, and polyhedral oligomeric metallasesquioxanes are attached to living and nonliving systems as biomaterials to provide a nanoscopic topology that favors biomimetic function and cellular modulation. The resulting surface is nanoscopically thin, nanoscopically dispersed, provides systematic chemistry, surface area, surface volume, surface topology, and is essentially free of impurities, and has controllable properties through selection of composition, R groups, nanostructure size and topology. Highly shape specific and chemically tailorable nanostructured molecules are sized to biological material dimensions and are compatible with all sterilization methods.