Process for preparing dispersible sulfate, preferably barium sulfate nanoparticles

US7575734B2 · kind B2 · utility

Assignee

• CENTRUM FUR ANGEWANDTE NANOTECHNOLOGIE (CAN) GMBH · DE

Inventors

• Michael Berkei · Haltern am See, DE
• Heiner Pfundt · Hamburg, DE

Key dates

• Filing date: May 4, 2004
• Grant date: Aug 18, 2009
• Expiry date: Nov 19, 2024

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/775
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is directed to a process for the manufacture of optionally doped nanoparticulate metal sulfate wherein the metal is selected from polyvalent metals or monovalent transition metals, said process comprising the step of heating a reaction mixture comprising a) a polar organic solvent comprising at least two hydroxy groups or a polar organic solvent comprising at least one sulfoxide group, b) a source of a polyvalent metal or monovalent transition metal, a sulfate source, and optionally a dopant metal source, and c) a base selected from i) bases having an aromatic N-containing heterocycle with the exception of imidazole, ii) bases having an aliphatic N-containing heterocycle, iii) aliphatic hydroxy-substituted amines, iv) aliphatic polyamines, v) aromatic amines, vi) ammonia and ammonia-releasing compounds, and vii) metal hydroxides. The invention is also directed to the resulting metal sulfate nanoparticles.