Activin-A mutants
US7575751B2 · kind B2 · utility
1Cited by
13References
8Claims
0Family size
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Key dates
| Filing date | Apr 27, 2005 |
| Grant date | Aug 18, 2009 |
| Priority date | — |
| Expiry date | Jun 9, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Members of the TGF-β superfamily control many physiologic and pathophysiologic processes in multiple tissues and signal via type II and type I receptor serine kinases. Type II activin receptors are promiscuous and known to bind 12 TGF-β ligands including activins, myostatin, BMPs and nodal. Methods are described for the screening and identification of antagonist for TGF-β superfamily members, in particular activin-A antagonist.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.