Patent · US Expired

Methods of inhibiting leptin-induced signaling with fibronectin III domain antibodies

US7575878B2 · kind B2 · utility

12Cited by

15References

3Claims

0Family size

Assignees

VIB VZW · BE
UNIVERSITEIT GENT · BE

Inventors

Jan Tavernier · Balegem, BE
Lennart ZABEAU · Evergem, BE

Key dates

Filing date	Nov 16, 2005
Grant date	Aug 18, 2009
Priority date	—
Expiry date	Nov 16, 2025

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/76
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to a new type of leptin receptor antagonist, which is able to prevent leptin signaling without preventing the binding of leptin to the leptin binding domain. More specifically, the invention relates to the use of a part of the leptin receptor to prevent the leptin-dependent activation of the receptor, and by this the leptin-induced signaling.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.