Compound combinations for inhibiting cell division and methods for their identification and use
US7575889B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 14, 2006 |
| Grant date | Aug 18, 2009 |
| Priority date | — |
| Expiry date | Mar 14, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/18
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides in vitro assays, e.g., FtsZ GTPase assays, and/or in vivo assays and methods of use thereof to identify particular compounds and combinations of compounds that affect microbial cell division. The invention further provides such compounds and compound combinations, including combinations that result in inhibition of cell survival or growth when present together at concentrations below their individual MICs. Certain of the compound combinations display synergism. Certain of the combinations include a compound that inhibits FtsZ GTPase activity and a compound that inhibits cell growth by a mechanism other than inhibition of FtsZ GTPase activity. The present invention further provides pharmaceutical compositions that have anti-microbial activity and methods of treating microbial infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.