Human recombinant beta-interferon with improved solubility

US7575894B2 · kind B2 · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Christian Schneider-Fresenius · Hannover, DE
• Bernd Otto · Hannover, DE
• Gero Waschutza · Meinersen, DE

Key dates

• Filing date: Nov 17, 2005
• Grant date: Aug 18, 2009
• Expiry date: Jul 28, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/565
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to variants of recombinant human beta interferon and to a method for the production thereof, wherein at least one of the following amino acids Leu(5), Phe(8), Phe(15), Leu(47), Phe(50), Leu(106), Phe(111), Leu(116), Leu(120) and Phe(156) is exchanged with hydrophilic amino acid with a hydroxy group, specially serine, tyrosine or threonine, resulting in enhanced hydrophilic property of the protein surface.