Pyrazole derivative, drug composition containing the same and production intermediate therefor
US7576064B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 15, 2004 |
| Grant date | Aug 18, 2009 |
| Priority date | — |
| Expiry date | Aug 30, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D231/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides pyrazole derivatives represented by the general formula:wherein R1 represents H, an optionally substituted C1-6 alkyl, etc.; one of Q and T represents a group selected from the following:and the other represents -Z-Ar wherein Z represents —O—, —S—, etc.; Ar represents an optionally substituted C6-10 aryl, etc.;R represents an optionally substituted C3-8 cycloalkyl, an optionally substituted C6-10 aryl, etc., pharmaceutically acceptable salts thereof, and prodrugs thereof, which exhibit an excellent inhibitory activity in human sodium/glucose cotransporter (SGLT) and are useful as agents for the prevention, inhibition of progression or treatment of a disease associated with the excess uptake of at least a kind of carbohydrates selected from glucose, fructose and mannose (diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications, etc.), and pharmaceutical compositions containing the same, medicinal uses thereof and intermediates for production therefor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.