Modified pyrimidine glucocorticoid receptor modulators
US7576076B2 · kind B2 · utility
32Cited by
1References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 29, 2005 |
| Grant date | Aug 18, 2009 |
| Priority date | — |
| Expiry date | Aug 19, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a compound having the formula:wherein, n and m are 1; X1 and X2 are O; R1 is a member selected from unsubstituted phenyl and substituted phenyl; R2 is a member selected from hydrogen, —CN, —OR2A, -L2A—C(O)R2B, -L2B—S(O)2R2C; R3 is a member selected from unsubstituted benzyl and substituted benzyl; R4 is a member selected from hydrogen and substituted or unsubstituted alkyl, wherein if R4 is methyl, then -L1-R1 is not benzyl or —C(O)—O—CH2—CH3; and L1 is a bond; and compositions and methods of using the compounds as glucocorticoid receptor modulators.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.