Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US7576121B2 · kind B2 · utility
8Cited by
62References
56Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 1, 2006 |
| Grant date | Aug 18, 2009 |
| Priority date | — |
| Expiry date | Jan 9, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F5/025
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that display selective, potent dipeptidyl peptidase IV (DPP-IV) inhibitory activity. These compounds are useful for the treatment of disorders that can be regulated or normalized via inhibition of DPP-IV including those characterized by impaired glycemic control such as Diabetes Mellitus and related conditions. The compounds can be administered alone or with another medicament that displays pharmacological activity for treatment of these and other diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.