Antibodies specific for sclerostin
US7578999B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 5, 2006 |
| Grant date | Aug 25, 2009 |
| Priority date | — |
| Expiry date | Nov 14, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/108
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel class or family of TGF-β binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.