Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof

US7579324B2 · kind B2 · utility

Assignee

• c-a-i-r biosciences GmbH · DE

Inventors

• Michael Burnet · Bingen, DE
• Jan-Hinrich Guse · Asperg, DE
• Hans-Jurgen Gutke · Stuttgart, DE
• Albert Beck · Nehren, DE
• Georgia Tsotsou · Lörrach, DE
• Irina Droste-Borel · Tübingen, DE
• Jeannette Reichert · Rottenburg am Neckar, DE
• Kattie Luyten · Tübingen, DE
• Maximilian Busch · Tübingen, DE
• Michael Wolff · Monheim, DE
• Moussa Khobzaoui · Tübingen, DE
• Simona Margutti · Reutlingen, DE
• Thomas Meindl · Tübingen, DE
• Gene Kim · Bingen, DE
• Laurence Barker · Bingen, DE

Key dates

• Filing date: Feb 14, 2003
• Grant date: Aug 25, 2009
• Expiry date: Feb 14, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/549
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention features a compound of the following formula:T-(-L-C)m,T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic agent, and m is 1, 2, 3, 4, 5, 6, 7, or 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2.