Patent · US Active

Adenosine receptor antagonists and methods of making and using the same

US7579354B2 · kind B2 · utility

0Cited by

11References

39Claims

0Family size

Inventors

William F. Kiesman · Cambridge, US
Carol L. Ensinger · Newark, US
Russell C. Petter · Stow, US
James E. Dowling · Lexington, US
Gnanasambandam Kumaravel · Westford, US
He Xi Chang · Belmont, US
Ko-Chung Lin · Lexington, US

Key dates

Filing date	Jul 10, 2006
Grant date	Aug 25, 2009
Priority date	—
Expiry date	Jul 10, 2026

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07F9/65616
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable.In one embodiment, the invention features a compound of formula I:

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.