Indolyl-3-glyoxylic acid derivatives having antitumor action

US7579365B2 · kind B2 · utility

Assignee

• ZIOPHRAM Oncology, Inc. · US

Inventors

• Bernd Nickel · Mühltal, DE
• Istvan Szelenyi · Arnstorf, DE
• Jurgen Schmidt · Grundau, DE
• Peter Emig
• Dietmar Reichert · Eschau, DE
• Eckhard Gunther · Offenbach, DE
• Kay Brune · Marloffstein, DE
• Guillaume Le Baut · Saint-Sébastien-sur-Loire, FR

Key dates

• Filing date: Dec 4, 2002
• Grant date: Aug 25, 2009
• Expiry date: Dec 24, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agentsand to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.