Fused heterocycles

US7579370B2 · kind B2 · utility

Assignee

• Sepracor, Inc. · US

Inventors

• Michele L. R. Heffernan · Worcester, US
• James M. Dorsey · Havertown, US
• Qun Kevin Fang · Wellesley, US
• Robert J. Foglesong · Durham, US
• Seth Cabot Hopkins · Northborough, US
• Cyprian O. Ogbu · Bellevue, US
• Mustapha Soukri · Raleigh, US
• Kerry L. Spear · Oakland, US

Key dates

• Filing date: Aug 3, 2007
• Grant date: Aug 25, 2009
• Expiry date: Aug 3, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides fused heterocycles having the formula:in which R1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R2 is a member selected from the group consisting of H substituted or unsubstituted alkenyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R3is a member selected from the group consisting of H, C1-C6 substituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl. R4 is a member selected from OH and O−X+, in which X+ is positive ion which is a member selected from organic positive ions and inorganic positive ions. Substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroarylalkyl moieties have the formula:in which Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl. The index n is an integer from 1 to 4.