Cyclic peptides as G-protein-coupled receptor antagonists
US7579432B2 · kind B2 · utility
3Cited by
1References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 17, 2002 |
| Grant date | Aug 25, 2009 |
| Priority date | — |
| Expiry date | Aug 19, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/472
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel cyclic compounds which have the ability to modulate the activity of G protein-coupled receptors. The compounds preferably act as antagonists. In preferred embodiments, the invention provides cyclic peptidic and peptidomimetic antagonists of C5a receptors, which are active against C5a receptors on polymorphonuclear leukocytes and macrophages. The compounds of the invention are both potent and selective, and are useful in the treatment of a variety of inflammatory conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.