Somatostatin-dopamine chimeric analogs

US7579435B2 · kind B2 · utility

Assignee

• Société de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS · FR

Inventors

• Michael DeWitt Culler · Gretna, US
• Zheng Xin Dong · Holliston, US
• Sun H. Kim · Needham, US
• Jacques-Pierre Moreau · Upton, US

Key dates

• Filing date: Jun 7, 2002
• Grant date: Aug 25, 2009
• Expiry date: May 15, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c-(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2.