Processes for the preparation of rocuronium bromide and intermediates thereof

US7579461B2 · kind B2 · utility

Assignee

• Chemagis Ltd. · IL

Inventors

• Eliezer Adar · Even Yehuda, IL
• David Sondack · Arad, IL
• Oded Friedman · Haifa, IL
• Iosef Manascu · Omer, IL
• Tamir Fizitzki · Beer Sheva, IL
• Boris Freger · Beer Sheva, IL
• Oded Arad · Rehovot, IL
• Alexander Weisman · Kiryat Ekron, IL
• Joseph Kaspi · Givatayim, IL

Key dates

• Filing date: Jan 13, 2005
• Grant date: Aug 25, 2009
• Expiry date: Aug 30, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J11/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A novel process for preparing (2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl) androstane, a known intermediate in the synthesis of the skeletal muscle relaxant rocuronium bromide, is disclosed.