3′ end tagged oligonucleotides
US7582436B2 · kind B2 · utility
17Cited by
12References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 18, 2007 |
| Grant date | Sep 1, 2009 |
| Priority date | — |
| Expiry date | Sep 25, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6853
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides compositions comprising oligonucleotides that have 3′ end groups (e.g. lipophilic moieties) that are useful in invasive cleavage reactions such as the INVADER assay. Specifically, the present invention provides compositions containing oligonucleotides with 3′ end groups configured for generating a detectable signal in invasive cleavages assays with a high signal-to-background ratio, as well as methods for generating such compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.