Cleaved serum response factor in cardiac diagnosis and therapy
US7582478B2 · kind B2 · utility
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1References
10Claims
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Assignee
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Key dates
| Filing date | Jan 22, 2004 |
| Grant date | Sep 1, 2009 |
| Priority date | — |
| Expiry date | Jan 22, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/325
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to the cleavage of serum response factor as it relates to cardiac disease. In specific embodiments, failing cardiac tissue is diagnosed in tissues comprising elevated cleavage of serum response factor. In further specific embodiments, heart failure is associated with cardiac myocyte apoptosis as a result of an increase in cleaved serum response factor, particularly by caspases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.