Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions

US7582625B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Stephan Georg Mueller · Warthausen, DE
• Klaus Rudolf · Warthausen, DE
• Philipp Lustenberger · Warthausen, DE
• Dirk Stenkamp · Biberach, DE
• Marco Santagostino · Magenta, IT
• Fabio Paleari · Monza, IT
• Henri Doods · Warthausen, DE
• Kirsten Arndt · Biberach, DE
• Gerhard Schaenzle · Biberach, DE

Key dates

• Filing date: Sep 19, 2006
• Grant date: Sep 1, 2009
• Expiry date: Feb 11, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the CGRP-antagonists of general formula Iwherein R1, R2, R3 and R4 are defined as in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, as well as those compounds of general formula I wherein one or more hydrogen atoms are replaced by deuterium, pharmaceutical compositions containing these compounds, their use and processes for preparing them.