Process for the synthesis of cPLA2 inhibitors

US7582771B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Christoph Martin Dehnhardt · New York, US
• Sreenivasulu Megati · New City, US
• Ronald Michalak · Congers, US
• Panolil Raveendranath · Rochester, US
• Jianxin Ren · Nanuet, US
• Charles C. Wu · North Wales, US
• Yangzhong Wu · The Bronx, US

Key dates

• Filing date: Aug 31, 2004
• Grant date: Sep 1, 2009
• Expiry date: May 10, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for making the compound of formula (I)wherein Ac represents acetate; X represents O or CH2; Y represents C1-C6alkyl; and Z is selected from the group consisting of H, halogen, CN, CHO, CF3, OCF3, OH, C1-C6alkyl, C1-C6alkoxy, C1-C6thioalkyl, NH2, N(C1-C6alkyl)2, NH(C1-C6alkyl), NC(O)—(C1C6alkyl), and NO2. In his process, a compound of formula (II)is reacted with hydrazine to form a primary alkylamine, and then the primary alkylamine is reacted with acetic anhydride, to produce the compound of formula (I).