Transporters comprising spaced arginine moieties
US7585834B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Feb 14, 2002 |
| Grant date | Sep 8, 2009 |
| Priority date | — |
| Expiry date | Jul 1, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compositions and methods for enhancing transport of biologically active compounds across biological membranes and across and into animal epithelial or endothelial tissues. The composition includes a biologically active agent and a transport moiety. The transport moiety includes a structure selected from the group consisting of (ZYZ)nZ, (ZY)nZ, (ZYY)nZ and (ZYYY)nZ. Subunit “Z” is L-arginine or D-arginine, and subunit “Y” is an amino acid that does not comprise an amidino or guanidino moiety. Subscript “n” is an integer ranging from 2 to 10. The method for enhancing transport involves the administration of the aforementioned composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.