Compositions and methods for inhibiting light-induced inactivation of biological reagents
US7588908B2 · kind B2 · utility
15Cited by
11References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 7, 2003 |
| Grant date | Sep 15, 2009 |
| Priority date | — |
| Expiry date | May 17, 2026 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/2525
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed is a fluorescent conjugate comprising a biological reagent, a fluorescent molecule, and a means for impeding phototoxic degradation of the biological reagent. The impeding means can be a cross-linking substance having a long molecular distance, whereby the cross-linking substance links the fluorescent molecule and the biological reagent; a quencher of singlet oxygen; a quencher of a free radical; or a combination thereof. Also disclosed is a solution comprising a fluorescent conjugate of a biological reagent and a fluorescent molecule together with an oxygen depleting system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.