High arachidonic acid producing strains of Yarrowia lipolytica
US7588931B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Nov 1, 2005 |
| Grant date | Sep 15, 2009 |
| Priority date | — |
| Expiry date | Jun 23, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA23V2002/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 10% arachidonic acid (ARA, an ω-6 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases, and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of ARA. Production host cells are claimed, as are methods for producing ARA within said host cells.
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