Patent · US Expired

Thrombin-cleavable chimeric proteins

US7589178B2 · kind B2 · utility

9Cited by

6References

24Claims

0Family size

Assignee

Institut National de la Sante et de la Recherche Medicale (INSERM) · FR

Inventors

Bernard Le Bonniec · Paris, FR
Pierre-Emmanuel Marque · Paris, FR
Virginie Louvain · Verrières-le-Buisson, FR
Claire Calmel · Paris, FR
Elsa Bianchini · Philadelphia, US
Martine Aiach · Sèvres, FR

Key dates

Filing date	Oct 18, 2002
Grant date	Sep 15, 2009
Priority date	—
Expiry date	Feb 24, 2024

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to chimeric proteins comprising an artificial sequence for cleavage by thrombin, in which the activation peptide is fibrinopeptide A. Preferably, said chimeric proteins are derived from the zymogen of a serine protease such as PC or FX, by replacing the activation peptide of said zymogen with fibrinopeptide A, or a portion thereof, comprising at least amino acids P10 to P1 of said fibrinopeptide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.