Patent · US Expired

Method and device for transporting or binding-specific separation of electrically charged molecules

US7591938B2 · kind B2 · utility

1Cited by

2References

27Claims

0Family size

Assignee

Siemens Aktiengesellschaft · DE

Inventors

Heike Barlag · Koblenzer Straße, DE
Walter Gumbrecht · Herzogenaurach, DE
Manfred Stanzel · Erlangen, DE

Key dates

Filing date	Nov 28, 2003
Grant date	Sep 22, 2009
Priority date	—
Expiry date	Apr 15, 2026

Classification

Technology area (CPC G)Physics
CPC primaryG01N27/3277
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Electrically charged molecules need to be transported in order to create a DNA sensor. The following measures are undertaken: base metals are introduced into a solution as a positive ion; negatively charged molecules are transported in an opposite direction and are enriched in the vicinity of the measuring electrodes. Binding-specific separation of the charged molecules can be achieved by forming metal layers on the measuring electrodes by depositing metal ions from the solution when a suitable potential is selected. Target DNA can more particularly be introduced into the vicinity of the catcher molecules on the measuring electrodes and non-specifically bound DNA can be removed. According to the associated device, the electrode arrangement may be associated with a sacrificial electrode made of more base metal than the material of the measuring electrodes. The measuring electrodes in particular may be made of noble metal, preferably gold, and the sacrificial electrode may be made of copper.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.