High resolution typing system for pathogenic Mycobacterium tuberculosum
US7592135B2 · kind B2 · utility
1Cited by
7References
33Claims
0Family size
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Key dates
| Filing date | Jul 13, 2005 |
| Grant date | Sep 22, 2009 |
| Priority date | — |
| Expiry date | Jul 13, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
MLVA methods for strain discrimination among Mycobacterium tuberculosum strains are disclosed. Nine VNTR loci have been identified from genomic sequences of Mycobacterium tuberculosum strains and primer pairs suitable for amplifying the VNTR by PCR are disclosed. Polymorphisms at these loci were used to resolve genotypes into distinct groups. This sub-typing scheme is useful for the epidemiological study of Mycobacterium tuberculosum and may be applied to the local detection of the pathological causative agent of tuberculosum.
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