Detection of gleevec resistance
US7592142B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 24, 2008 |
| Grant date | Sep 22, 2009 |
| Priority date | — |
| Expiry date | Jul 24, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/82
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.