Polypeptide cleavage process
US7592432B2 · kind B2 · utility
1Cited by
6References
47Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 24, 2004 |
| Grant date | Sep 22, 2009 |
| Priority date | — |
| Expiry date | Jul 26, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/60
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides a palladium-promoted hydrolytic polypeptide cleavage process which selectively cleaves the polypeptide at a Cys-His cleavage site comprising solubilizing the polypeptide in a reaction mixture comprised of a palladium promoter dissolved in a high-concentration formic acid, wherein the concentration of the formic acid in the reaction mixture is between about 1 to about 22 molar.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.