Patent · US Active

Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride

US7592459B2 · kind B2 · utility

3Cited by

12References

7Claims

0Family size

Assignee

Chemagis Ltd. · IL

Inventors

Oded Arad · Rehovot, IL
Lior Zelikovitch · Mazkeret Batya, IL
Mohammed Alnabari · Hora, IL
Michael Brand · Edison, US
Irina Gribun · Bat Yam, IL
Ada Salman · Ramat Gan, IL
Meital Shiffer · Nes Ziona, IL
Moty Shookrun · Netanya, IL
Orna Kurlat · Beer Sheva, IL
Moshe Bentolila · Afula, IL
Joseph Kaspi · Givatayim, IL

Key dates

Filing date	Sep 27, 2005
Grant date	Sep 22, 2009
Priority date	—
Expiry date	Feb 27, 2027

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P25/28
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention provides a crystalline donepezil maleate, which is used as an intermediate in the preparation of donepezil hydrochloride. Also provided are novel processes for producing same in substantially pure form and a process for producing pharmaceutically pure amorphous donepezil hydrochloride therefrom.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.