Methods for determining specificity of RNA silencing and for genetic analysis of the silenced gene or protein
US7592504B2 · kind B2 · utility
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Key dates
| Filing date | Jun 14, 2006 |
| Grant date | Sep 22, 2009 |
| Priority date | — |
| Expiry date | Mar 18, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/11
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods and kits for determining the specificity of siRNAs for their targets are provided. Also provided is a method for performing genetic analysis of the target protein or gene using different versions of a synthetic gene to complement the phenotype induced by RNAi-mediated silencing of the target protein and/or gene of interest. Finally, a method for treating genetic disorders associated with production of mutated proteins is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.