Methods and apparatus for use in genetics classification including classification tree analysis
US7593816B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Dec 2, 2002 |
| Grant date | Sep 22, 2009 |
| Priority date | — |
| Expiry date | Oct 30, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B40/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
Methods and apparatus for use in genetic trait classification involving at least two genes associated with a genetic trait are described. In one illustrative method, a value for use in classifying an individual into one of a plurality of trait classes associated with the genetic trait is calculated. The value is calculated based on (1) a sum of contributions associated with each genotype of a plurality of genotypes of the at least two genes identified for the individual, where the contributions for each genotype are identified at least in part from statistical associations between the genotypes and each trait class identified in a sample population; and (2) a sum of contributions associated with each one of one or more genotype combinations between the at least two genes identified in the individual, where the contributions for the one or more genotype combinations are identified at least in part from statistical associations between the genotype combinations and each trait class identified in the sample population. Advantageously, epistasis as well as additivity and dominance affects are taken into account for more accurate genetic trait classifications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.