Crystal structure of human Janus Kinase 2 (JAK2) and uses thereof
US7593820B2 · kind B2 · utility
62Cited by
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5Claims
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Key dates
| Filing date | Oct 11, 2005 |
| Grant date | Sep 22, 2009 |
| Priority date | — |
| Expiry date | Oct 11, 2025 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A90/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to X-ray crystallography studies of a human Janus Kinase 2 (JAK2) domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to a inhibitor. The invention further relates to the use of the crystal and related structural information to select and screen for compounds that interact with JAK2 and related proteins and to compounds that could be used for the treatment of diseases mediated by inappropriate JAK2 activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.