Methods and compositions for modulating T lymphocytes
US7595148B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 23, 2004 |
| Grant date | Sep 29, 2009 |
| Priority date | — |
| Expiry date | Nov 26, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/70517
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This invention provides novel methods and compositions for modulating T cell differentiation and T cell responses. The modulators are identified by screening test compounds for ability to modulate an inositol 1,4,5-trisphosphate 3-kinase (IP3K). The IP3K modulators can be further examined for their activity in modulating development of progenitor T cells (e.g., CD4+/CD8+ double positive T cells) into mature CD4+ or CD8+ single positive T cells. Pharmaceutical compositions comprising these T cell modulators can be administered to a subject to modulate T cell immune responses, to suppress inflammations, and to treat disease conditions such as autoimmune diseases, graft rejection or allergies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.