Genes for synthesis of FR-008 polyketides
US7595156B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 6, 2004 |
| Grant date | Sep 29, 2009 |
| Priority date | — |
| Expiry date | Feb 10, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/08
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived from Streptomyces sp. FR-008. This base sequence comprises genes coding for ketosynthase (KS), acyl transferase (AT), acyl carrier protein (ACP), ketoreductase (KR), dehydratase (DH) and enoyl reductase (ER) domains, and genes coding for modifier enzymes, such as ABC transporter, cytochrome P450 monooxygenase, ferredoxin, thioesterase, sugar synthetic protein, FAD-dependent monooxygenase, 4-amino-4-deoxychorismate (ADC) synthase and ADC lyase. The gene base sequence according to the present invention can be used to increase the productivity of the existing FR-008 polyketides or produce new FR-008 polyketides, through modification of its parts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.