Method of measuring activation of effector cells
US7595165B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 15, 2003 |
| Grant date | Sep 29, 2009 |
| Priority date | — |
| Expiry date | Sep 15, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/70535
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to a method of measuring the activation of an effector cell belonging to the immune system, which may or may not be transformed, using a monoclonal (AcMo) or polyclonal antibody. The invention is characterised in that it consists in: bringing into contact (i) CD16 receptor-expressing cells in a reaction medium in the presence of the antibody and (ii) the antigen of said antibody, and measuring the quantity of at least one cytokine produced by the CD16 receptor-expressing cell. The invention also relates to the selection of an antibody capable of inducing the expression of cytokines and interleukins, such as IFN? or IL2 which are intended for the treatment of autoimmune and inflammatory diseases, cancers and infections by pathogens.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.