Cytotoxin-based biological containment
US7595185B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 10, 2006 |
| Grant date | Sep 29, 2009 |
| Priority date | — |
| Expiry date | Sep 12, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/68
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including the E. coli relBE locus and similar systems found in Gram-negative and Gram-positive bacteria and Archae. Such system are generally based on a cytotoxin polypeptide and an antitoxin or antidote polypeptide that in contrast to the cytotoxin is degradable by proteases. The recombinant cells are useful as vaccines, pollutant degrading organisms or as biological pest control organisms e.g. expressing B. thuringiensis crystalline proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.