Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions

US7595312B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Klaus Rudolf · Warthausen, DE
• Stephan Georg Mueller · Warthausen, DE
• Dirk Stenkamp · Biberach, DE
• Philipp Lustenberger · Warthausen, DE
• Alexander Dreyer · Ochsenhausen, DE
• Eckhart Bauer · Biberach, DE
• Marcus Schindler · Schwäbisch Hall, DE
• Kirsten Arndt · Biberach, DE
• Henri Doods · Warthausen, DE

Key dates

• Filing date: Oct 16, 2003
• Grant date: Sep 29, 2009
• Expiry date: May 6, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to CGRP antagonists of general formulawherein A, U, V, W, X and R1 to R3 are defined as in claim 1, the tautomers, diastereomers, enantiomers, hydrates, mixtures thereof and the salts thereof as well as the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them.