Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases

US7595317B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Jingwu Duan · Yardley, US
• Bin Jiang · Norristown, US
• Lihua Chen · Boothwyn, US
• Zhonghui Lu · King of Prussia, US
• Joseph Barbosa · Lambertville, US
• William J. Pitts · Newtown, US

Key dates

• Filing date: Apr 5, 2007
• Grant date: Sep 29, 2009
• Expiry date: Sep 28, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present application describes novel barbituric acid derivatives of formula I:or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, Ua, Xa, Ya, and Za are defined in the present specification, which are useful as TNF-α converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.