Heterocyclic sulfonamides as modulators of cardiac sarcomeres

US7595322B2 · kind B2 · utility

Assignee

• CYTOKINETICS, INC. · US

Inventors

• Bradley P. Morgan · Moraga, US
• Fady Malik · Burlingame, US
• Erica Anne Kraynack · South San Francisco, US
• Alexander Ramon Muci · San Francisco, US
• Xiangping Qian · Foster City, US
• David J. Morgans, Jr. · Los Altos, US

Key dates

• Filing date: Mar 26, 2004
• Grant date: Sep 29, 2009
• Expiry date: Mar 19, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Certain substituted sulfonamide derivatives of Formula I selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.