Method for protecting normal cells from cytotoxicity of chemotherapeutic agents

US7595347B2 · kind B2 · utility

Assignee

• Temple University-Of The Commonwealth System of Higher Education · US

Inventors

• Stephen Cosenza · Voorhees, US
• M. V. Ramana Reddy · Upper Darby, US
• E. Premkumar Reddy · Villanova, US

Key dates

• Filing date: May 21, 2004
• Grant date: Sep 29, 2009
• Expiry date: May 21, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/35
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pre-treatment with α,β unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the α,β unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic.