Methods and compositions for heat activated gene therapy using cytolethal distending toxin
US7595386B2 · kind B2 · utility
6Cited by
0References
3Claims
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Inventor
Key dates
| Filing date | Jan 23, 2004 |
| Grant date | Sep 29, 2009 |
| Priority date | — |
| Expiry date | Nov 30, 2024 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides compositions and methods for gene therapy using cytolethal distending toxins (CDTs). In a preferred embodiment, a gene therapy vector according to the invention includes a gene encoding a B subunit of a CDT and an antisense oligonucleotide that inhibits a DNA repair mechanism. An inducible promoter is operably linked to the gene and oligonucleotide. Preferably, the promoter is strictly inducible by heat shock.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.