Optical fluorescent imaging

US7597878B2 · kind B2 · utility

Assignee

• LI-COR, Inc. · US

Inventors

• Joy Kovar · Lincoln, US
• Jiyan Chen · Lincoln, US
• Daniel R. Draney · Norwalk, US
• D. Michael Olive · Lincoln, US
• William M. Volcheck · Lincoln, US
• Xinshe Xu · Lincoln, US
• Ananda G. Lugade · Austin, US
• Narasimhachari Narayanan · Lincoln, US

Key dates

• Filing date: May 19, 2006
• Grant date: Oct 6, 2009
• Expiry date: Oct 11, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C09B23/0066
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.