Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a chloride intracellular channel 1 protein
US7598050B2 · kind B2 · utility
1Cited by
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14Claims
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Key dates
| Filing date | Dec 8, 2006 |
| Grant date | Oct 6, 2009 |
| Priority date | — |
| Expiry date | Feb 20, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/5406
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a chloride intracellular channel 1 (CLIC1) as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.