Dual chain synthetic heparin-binding growth factor analogs

US7598224B2 · kind B2 · utility

Assignee

• BioSurface Engineering Technologies, Inc. · US

Inventors

• Paul O. Zamora · Gaithersburg, US
• Louis A. Pena · Poquott, US
• Xinhua Lin · Plainview, US

Key dates

• Filing date: Feb 24, 2005
• Grant date: Oct 6, 2009
• Expiry date: May 23, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties separated by a first linker of from 3 to about 20 backbone atoms, which peptide chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a second linker, which may be a hydrophobic second linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.