Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted-benzylsulfones for treating proliferative disorders

US7598232B2 · kind B2 · utility

Assignees

• Temple University-Of The Commonwealth System of Higher Education · US
• ONCONOVA THERAPEUTICS, INC. · US

Inventors

• E. Premkumar Reddy · Villanova, US
• M. V. Ramana Reddy · Upper Darby, US
• Stanley C. Bell · Narberth, US

Key dates

• Filing date: Feb 28, 2003
• Grant date: Oct 6, 2009
• Expiry date: Dec 10, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/15
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula (I); wherein: X, X1, X2, Ra, R1, R2,R3, R4, R5, R6, R7, g, M, y, a, b, d, e, V, W, Z and Q are as defined herein.