Carboxamide derivatives and their use as factor Xa inhibitors

US7598241B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Dieter Dorsch · Ober-Ramstadt, DE
• Bertram Cezanne · Mörfelden, DE
• Werner Mederski · Zwingenberg, DE
• Christos Tsaklakidis · Weinheim, DE
• Johannes Gleitz · Darmstadt, DE
• Christoph van Amsterdam · Darmstadt, DE

Key dates

• Filing date: Jan 8, 2004
• Grant date: Oct 6, 2009
• Expiry date: Aug 15, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6533
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel compounds of the formula (I) in which R1, D, X, W, Y and T have the meaning indicated in Patent Claim (1), e.g. (II), are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.