Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols, compositions thereof, and methods for their use

US7598248B2 · kind B2 · utility

Assignee

• CYTOKINETICS, INC. · US

Inventors

• Alex Muci · South San Francisco, US
• Jeffrey T. Finer · Foster City, US
• Pu-Ping Lu · Foster City, US
• Alan J. Russell · Boulder, US
• Bradley P. Morgan · Moraga, US
• David J. Morgans, Jr. · Los Altos, US

Key dates

• Filing date: Aug 1, 2007
• Grant date: Oct 6, 2009
• Expiry date: Aug 1, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided is at least one chemical entity chosen from compounds of Formula I and compounds of Formula II:and pharmaceutically acceptable salts thereof, compositions thereof, and methods for their use in modulating of one or more of skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, skeletal muscle, and skeletal sarcomere.